The beginning of atherosclerosis is leukocyte adhere to the vascular endothelial cells which have been injured. If we can control that we also control the onset and development of the atherosclerosis. There are the reports that the anti-hypercholesterolemia grug cervastatin act on leukocyte and inhibits their adhesion to the vascular endothelial cells. We observe the phenomenon of leukocyte adhesive interaction to the vascular endothelial cells and confirm the effects of cerivastatin.